Basic Information
VIS ID
TVIS44001066
Fusion event
HTLV-1-SLC8A3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
70586884/70120167 (Hg38)
End
70586884/70120167 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
SLC8A3
miRNAs that regulate target gene
hsa-mir-874-5p ; hsa-mir-5699-5p ; hsa-mir-298 ; hsa-mir-5008-5p ; hsa-mir-6868-5p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-186-3p ; hsa-mir-759 ; hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-5000-5p ; hsa-mir-6769a-3p
Nearest miRNA
hsa-mir-208a/Upstream/2678237; hsa-mir-1185-1/Downstream/2396653;
Nearest TSS
ENST00000550708/Upstream/39961; ENST00000554008/Downstream/48317;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/73890, chr14-CpG: 22/Downstream/67474
Upstream sequence
tatgccagagcaactctgccatccctgaatggtggagccaatacgatggaagctgcctgcatccccatccccaagttgtggcttagataactgcctgacc
Downstream sequence
aggacattcaactttatatgagtaagaaataaactttcactgagtaagccaatgagatttggaagttatttctgcagctagcgtgaaataccatgactaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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