VISDB - VIS Detail

Basic Information

VIS ID

TVIS44001069

Fusion event

HTLV-1-SMTNL2 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr17

Cytoband

p13.2

Reference genome

GRCh37/hg19

Start

4506572/4603277 (Hg38)

End

4506572/4603277 (Hg38)

Orient

Location type

Intronic

Target gene

SMTNL2

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-744-3p ; hsa-mir-106a-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-7158-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-3937 ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3714 ; hsa-mir-4293 ; hsa-mir-6771-3p ; hsa-mir-1273g-3p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-3664-5p ; hsa-mir-3672 ; hsa-mir-4252 ; hsa-mir-4522 ; hsa-mir-4793-3p ; hsa-mir-4797-5p ; hsa-mir-508-5p ; hsa-mir-5189-5p ; hsa-mir-5586-3p ; hsa-mir-612 ; hsa-mir-6510-3p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6860 ; hsa-mir-6864-3p ; hsa-mir-759 ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-873-3p ; hsa-mir-939-3p

Nearest miRNA

hsa-mir-1253/Upstream/1855095; hsa-mir-10226/Downstream/366425;

Nearest TSS

ENST00000595228/Upstream/8211; ENST00000573270/Downstream/7172;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/6239, chr17-CpG: 17/Downstream/3982

Upstream sequence

ggaaaatgccggcaattctgagggcctcctatgaagtgggttagggagtggcaagacctggttcggagaggtgggtcctgggtatcctttgtgggaacag

Downstream sequence

ttaaggaaccagagctgtttagttcagagaaagacatggaaggaaggttttcttctggcgtgtgaagggttctgacatgggggaaaaatcagactgagaa

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.