Basic Information
VIS ID
TVIS44001087
Fusion event
HTLV-1-chr1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
179697942/179728807 (Hg38)
End
179697942/179728807 (Hg38)
Orient
-
Location type
Intronic
Target gene
FAM163A ; LOC105371635
miRNAs that regulate target gene
hsa-mir-658 ; hsa-mir-1273g-3p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-933 ; hsa-mir-4783-5p ; hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-6889-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-6503-5p ; hsa-mir-4527 ; hsa-mir-103a-2-5p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-409-5p ; hsa-mir-4318 ; hsa-mir-4693-5p ; hsa-mir-892a
Nearest miRNA
hsa-mir-101-1/Upstream/1050973; hsa-mir-1182/Downstream/75117;
Nearest TSS
ENST00000473358/Upstream/88856; ENST00000423879/Downstream/1410;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/136346, chr1-CpG: 197/Downstream/14005
Nearby gene
FAM163A(+14356) ;
Upstream sequence
CACTATTTAGGAGCACTTAAACCACCAAAGATTAGCCACAGTGGCAAAATAATAAAGCTATTGGTTTAATCTACAATCAAGGTAAACTAGCGGAAGGCAA
Downstream sequence
AGATGACTAAATGGTTTTTGTCCTGAAGTCACTGTAGTGCCTTTCCTCAGAGTGCCAGCTCACTCCCCGAGACATCGATACATGTTTGTGTCAAGACCTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate