Basic Information
VIS ID
TVIS44001100
Fusion event
HTLV-1-ZNF280D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
57010140/56717942 (Hg38)
End
57010140/56717942 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF280D
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-505-5p ; hsa-mir-3194-5p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-10393/Upstream/1344908; hsa-mir-11181/Downstream/2453241;
Nearest TSS
ENST00000557528/Upstream/10624; ENST00000621974/Downstream/15552;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/252757, chr15-CpG: 88/Downstream/15257
Upstream sequence
tggaatatttggaataccaaattacagggaggcagacttcatctcaatataagaacaaaacaattagcagttaaaatatcaaaaacgaagatgaactCTA
Downstream sequence
GGTGAGAAAGATCATCAAAGAAAAATATGAAAAATTTAAACATTATGTGACTGAAAATGTTCACTTTCAAGATCCCTTCAAGAACCCTTCCAACCCTAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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