Basic Information
VIS ID
TVIS44001116
Fusion event
HTLV-1-GCNT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
10530598/10530365 (Hg38)
End
10530598/10530365 (Hg38)
Orient
-
Location type
Intronic
Target gene
GCNT2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-98-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-3691/Upstream/90571; hsa-mir-10398/Downstream/5611191;
Nearest TSS
ENST00000381078/Upstream/553; ENST00000640968/Downstream/25642;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/103960, chr6-CpG: 56/Downstream/164019
Upstream sequence
gaggcaggagaatcgcttgaacccaaggggcggaggttgcaatgagccaagattgtgccactgcactccagcctgggtgacagatcgagactccatctct
Downstream sequence
aaataaataaataaataaaATGTAAACCTTATTCTCCTTTAAGCGCAACGCATTTAAAATCAGGAATATGTATTATAAATAAAATTTGAATGACAATTTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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