Basic Information
VIS ID
TVIS44001121
Fusion event
HTLV-1-PDGFRL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37/hg19
Start
17475086/17617577 (Hg38)
End
17475086/17617577 (Hg38)
Orient
-
Location type
Intronic
Target gene
PDGFRL
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-124-1/Upstream/2764067; hsa-mir-10400/Downstream/64001;
Nearest TSS
ENST00000518652/Upstream/41144; ENST00000523248/Downstream/16494;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/40132, chr8-CpG: 128/Downstream/183080
Nearest cancer related gene
PDGFRL(TSG, No orient, 0)
Upstream sequence
TCCTTGTCTCCCTTGCGTGACACGGACTCAGCCTGCAGAGGCCCTCGGTCACTTCCAACCCCTTGCGTAGTCTGCTGCCTAGACGATGAGATACCATTGG
Downstream sequence
TAGAAATGGACATTCTAAATCCAGGCCCTGAAACTGTAATCCCACTAAATAATTTGTTTCCTGTTTTATATTGTTTGCGTAGAAGAGGGGGTGGAAAAAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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