Basic Information
VIS ID
TVIS44001122
Fusion event
HTLV-1-TRAPPC9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
141459598/140449499 (Hg38)
End
141459598/140449499 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
TRAPPC9
miRNAs that regulate target gene
hsa-mir-30e-5p ; hsa-mir-196a-5p ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-6873-5p ; hsa-mir-583
Nearest miRNA
hsa-mir-1204/Upstream/5644554; hsa-mir-10400/Downstream/283065;
Nearest TSS
ENST00000518652/Upstream/14302; ENST00000518971/Downstream/1431;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/99977, chr8-CpG: 78/Downstream/7620
Upstream sequence
AGCTGCTGCCTAGGCTTGCATCTCATCCAGCTCTGCAGAACAGCCACCATGGCAAGACACAGCAGCAAGCAGAGAGTGGAAGGAAGTGGCAAGGAAGAGC
Downstream sequence
TCATCTGCAATTTTGATTTGAAATAAAGTTTTTGACTTAATAACAGGCAAGATGGGAAGCTGACCTTTTCCTGCTCTATCCAACACTCCTTGTACACAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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