Basic Information
VIS ID
TVIS44001146
Fusion event
HTLV-1-MARCO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
119737103/118979527 (Hg38)
End
119737103/118979527 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
MARCO
Nearest miRNA
hsa-mir-1285-2/Upstream/5258159; hsa-mir-10b/Downstream/8444010;
Nearest TSS
ENST00000437798/Upstream/26544; ENST00000494979/Downstream/13490;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/120277, chr2-CpG: 28/Downstream/32040
Upstream sequence
accaggaacatggttgggtggttgacctctgaggatccttccaaagctggaaCAACACAGTTCTCTTTATAGATGGGAAAGGGAGACCCAGACTTTCTCA
Downstream sequence
AGGTGGTCCTGCCAGCCCCAGAGAAGGGGCCTCAGCCAGGTCTTTGCCCACTGAGTCTGAGTTATGCAGCTTCCCAACCACACTGTCACAAAGGCACGCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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