Basic Information
VIS ID
TVIS44001152
Fusion event
HTLV-1-CACNA2D3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
54502925/54468898 (Hg38)
End
54502925/54468898 (Hg38)
Orient
+
Location type
Intronic
Target gene
CACNA2D3
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6516-3p ; hsa-mir-92a-1-5p ; hsa-mir-6503-3p ; hsa-mir-8075 ; hsa-mir-8069 ; hsa-mir-664a-3p ; hsa-mir-758-5p ; hsa-mir-4728-3p ; hsa-mir-6074
Nearest miRNA
hsa-let-7g/Upstream/1622346; hsa-mir-12124/Downstream/1383594;
Nearest TSS
ENST00000440867/Upstream/196124; ENST00000471865/Downstream/432357;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/345900, chr3-CpG: 33/Downstream/157264
Nearest cancer related gene
CACNA2D3(TSG, No orient, 0)
Upstream sequence
aacaaagctgctgggaagttcgaactgggtggagcccactgcagctcagcaaagccactgtagccggactgcctctcttgcctcctttctgggtacgaca
Downstream sequence
tctctgaaagaaaggcagcagccccggttaggggcttatagatcaaactcccatctccctggtaaagagcacctgggggatggggtggctgtgggtacag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate