Basic Information
VIS ID
TVIS44001157
Fusion event
HTLV-1-TBC1D1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
37894602/37892981 (Hg38)
End
37894602/37892981 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D1
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-193b-3p ; hsa-mir-7-1-3p ; hsa-mir-125a-5p ; hsa-mir-299-5p ; hsa-mir-548au-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-3714
Nearest miRNA
hsa-mir-12113/Upstream/650990; hsa-mir-1243/Downstream/975051;
Nearest TSS
ENST00000502981/Upstream/1882; ENST00000504686/Downstream/9017;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1288, chr4-CpG: 98/Downstream/84100
Nearest cancer related gene
TBC1D1(OG, No orient, 0)
Upstream sequence
TGATAATCCCTGTCCCCCACTTCCCTAGAAGACAGCTTTGACCAGGAAGGCTGCAATGACAATGAGATGTACCCCTATGCAGAGCCAGATGTGGGCGGGT
Downstream sequence
GGCTTTTTTGTGGTCCAGATCTTCTAGGATCTTCTAGGATGTAACCCTGGCAAGCAGTGGGGAGCCTGAATCAAGCAGCATGGCTGTTACCTCTTCTGTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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