Basic Information
VIS ID
TVIS44001162
Fusion event
HTLV-1-DELE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
141317943/141938378 (Hg38)
End
141317943/141938378 (Hg38)
Orient
+
Location type
Intronic
Target gene
DELE1
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-let-7c-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10397/Upstream/1290452; hsa-mir-103a-1/Downstream/1741482;
Nearest TSS
ENST00000502646/Upstream/1304; ENST00000607378/Downstream/14041;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/14309, chr5-CpG: 61/Downstream/30588
Upstream sequence
cctgacagcacagtaggtattgaacaaatggtagctGCTCTGATGATTTTGTAGGAGAGACAATATCCCAAGGTTGCCTGAATTACCCTTCTAGGGCTCT
Downstream sequence
AAGAGCCCTGCTCACTCATGAGTCACTGGGGTTGGGAGTTAACAATGCCTGGGGAACCAAGCCCTTGAAGAAGTGCTGGCTCCAAAGTAGGAGTCCAAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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