Basic Information
VIS ID
TVIS44001169
Fusion event
HTLV-1-DSE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
116732958/116411795 (Hg38)
End
116732958/116411795 (Hg38)
Orient
+
Location type
Intronic
Target gene
DSE
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-599 ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-3161 ; hsa-mir-1251-3p ; hsa-mir-627-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-629-3p ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-4291 ; hsa-mir-153-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-6776-3p ; hsa-mir-1255b-2-3p
Nearest miRNA
hsa-mir-10398/Upstream/9627575; hsa-mir-1202/Downstream/2657252;
Nearest TSS
ENST00000381078/Upstream/12400; ENST00000606265/Downstream/670;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/40090, chr6-CpG: 78/Downstream/50109
Upstream sequence
AATCATAATTTCTAGAAACCACATGAAGTTTACTATTTTACCTTTTTCCAAGAGCCTGTTGATATGAGAAATATTTTAAAGTATTACTGAAACCAGTTTG
Downstream sequence
AATCTTTTGCCTTCTGCTTTTCTACTATAACCTGTAACTTGGTCAGAGAAGTTGGGACAATATGATTACATTCAGCATTTGGGGTCAACTTTTATTTTCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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