Basic Information
VIS ID
TVIS44001190
Fusion event
HTLV-1-SEC31B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
102270633/100510876 (Hg38)
End
102270633/100510876 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SEC31B
miRNAs that regulate target gene
hsa-mir-5096 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-6832-3p ; hsa-mir-6729-3p ; hsa-mir-4714-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p
Nearest miRNA
hsa-mir-107/Upstream/1586308; hsa-mir-1307/Downstream/464109;
Nearest TSS
ENST00000439456/Upstream/2083; ENST00000528044/Downstream/6119;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/28074, chr10-CpG: 66/Downstream/8529
Upstream sequence
AAAACAGCAGAGCCAACACAATGCTAGCTAAGAGGCTACTGCCAGAAAGGCTGTTTTCTAAGGTTGCAATGATCTTAATACAGCAGAAGGATGTTTTTCC
Downstream sequence
ATACAGGCTGAAGAGGCTGCCATGTCATCCAGGGACTGGAGCTCAGCAGGGGTAGAGGGCATGTCAACTGAGTAGCTAGAGAAGCCCACAGTAGGTCACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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