Basic Information
VIS ID
TVIS44001195
Fusion event
HTLV-1-PIK3C2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17216239/17194692 (Hg38)
End
17216239/17194692 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PIK3C2A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-22-3p ; hsa-mir-21-5p ; hsa-let-7i-5p ; hsa-mir-182-5p ; hsa-mir-26a-5p ; hsa-mir-544a ; hsa-mir-6878-3p ; hsa-mir-378a-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6778-3p ; hsa-mir-4454 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-212-5p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6813-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-518a-5p ; hsa-mir-218-1-3p
Nearest miRNA
hsa-mir-210/Upstream/1225071; hsa-let-7a-2/Downstream/1193095;
Nearest TSS
ENST00000527297/Upstream/24951; ENST00000620945/Downstream/13228;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/116733, chr11-CpG: 68/Downstream/12772
Nearby gene
PIK3C2A(-24885) ;
Upstream sequence
aaagttgttagacattggatgataagattcattctagcctggcgcagtggctcatgcctgtaatcccagcactttgagaggccaaagcaggtggatcacc
Downstream sequence
tgaggtcagaagttcaagaccagcctcaccaacatggtgaaactccacctctactaaaaatacaaaattagctgggcatggtggcacatgcctgttatcc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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