Basic Information
VIS ID
TVIS44001202
Fusion event
HTLV-1-COX6A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
120878372/120440569 (Hg38)
End
120878372/120440569 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA12E ; FRA12C
Target gene
COX6A1
miRNAs that regulate target gene
hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-27b-5p ; hsa-mir-4720-3p ; hsa-mir-5003-3p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-3064-3p ; hsa-mir-4786-5p ; hsa-mir-6757-5p ; hsa-mir-6788-5p ; hsa-mir-6871-5p ; hsa-mir-4792 ; hsa-mir-6882-5p ; hsa-mir-3974 ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p
Nearest miRNA
hsa-let-7i/Upstream/285070; hsa-mir-3612/Downstream/282624;
Nearest TSS
ENST00000382841/Upstream/598; ENST00000229384/Downstream/5801;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/2006, chr12-CpG: 70/Downstream/5675
Upstream sequence
ATGGTAACCATACTCTATTCCATAACCCTCATGTGAATCCACTTCCAACTGGCTACGAAGATGAATAAAGAGAATCTGGACCACTACCCGGGCACCAGGG
Downstream sequence
ACCACAGCACTGGTTTGGACCGTTACTCTGCACATGGACCAGAAAAAGTATATGGGACCTTAAGCTCACCTTCTTTACTTGTATCAAATGATGACTGGTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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