Basic Information
VIS ID
TVIS44001204
Fusion event
HTLV-1-SLC4A8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
51884509/51490725 (Hg38)
End
51884509/51490725 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
SLC4A8
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1256513; hsa-let-7i/Downstream/1408164;
Nearest TSS
ENST00000382841/Upstream/21656; ENST00000548616/Downstream/3626;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/65343, chr12-CpG: 75/Downstream/99965
Upstream sequence
gaaggaggggagaaaagcagtctagtcaggcccttaggtgggaaagagtgatatgtgttctacgaaatatcagggccatgtggctcatgggcattgagtc
Downstream sequence
aagacaagagcacagtgcaatgagaaggaaagagaggcaggggcagatcatgtagggccttgtcgacagtgggcaaggtaacctttgaagggttttaaca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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