VISDB Viral Integration Site DataBase

VIS ID

TVIS44001205

Fusion event

HTLV-1-CBX5 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr12

Cytoband

q13.13

Reference genome

Start

End

54668229/54274445 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-98-5p ; hsa-mir-1-3p ; hsa-mir-484 ; hsa-mir-339-5p ; hsa-mir-320a ; hsa-mir-197-3p ; hsa-mir-92a-3p ; hsa-let-7e-5p ; hsa-let-7b-5p ; hsa-mir-345-5p ; hsa-mir-4795-3p ; hsa-mir-1343-3p ; hsa-mir-6716-5p ; hsa-mir-6783-3p ; hsa-mir-6852-5p ; hsa-mir-6736-3p ; hsa-mir-548p ; hsa-mir-4438 ; hsa-mir-4635 ; hsa-mir-488-3p ; hsa-mir-583 ; hsa-mir-4650-5p ; hsa-mir-1304-5p ; hsa-mir-6878-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-6721-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-4763-3p ; hsa-mir-6781-3p ; hsa-mir-1207-5p ; hsa-mir-2682-3p ; hsa-mir-4721 ; hsa-mir-3616-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-548at-5p ; hsa-mir-376a-2-5p ; hsa-mir-202-3p ; hsa-mir-6831-5p ; hsa-mir-4668-3p ; hsa-mir-3927-3p ; hsa-let-7a-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7g-5p ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-mir-4500 ; hsa-let-7f-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-4477a ; hsa-mir-4316 ; hsa-mir-1294 ; hsa-mir-4677-3p ; hsa-mir-16-1-3p ; hsa-mir-126-5p ; hsa-mir-5683 ; hsa-mir-370-5p ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4252 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-3937 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-449b-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-6771-5p ; hsa-mir-7977 ; hsa-mir-566 ; hsa-mir-4743-5p ; hsa-mir-4268 ; hsa-mir-6720-3p ; hsa-mir-20b-3p ; hsa-mir-6746-5p ; hsa-mir-4267 ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-4256 ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-4735-5p ; hsa-mir-6742-3p ; hsa-mir-939-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1180-5p ; hsa-mir-1343-5p ; hsa-mir-2110 ; hsa-mir-3150a-3p ; hsa-mir-3175 ; hsa-mir-3908 ; hsa-mir-450a-2-3p ; hsa-mir-509-3p ; hsa-mir-6763-5p ; hsa-mir-6810-5p ; hsa-mir-6825-5p ; hsa-mir-6857-5p ; hsa-mir-7114-3p ; hsa-mir-7973 ; hsa-mir-92a-1-5p ; hsa-mir-939-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/42969; hsa-let-7i/Downstream/62771;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/56191, chr12-CpG: 18/Downstream/5093

Nearest cancer related gene

CBX5(TSG, No orient, 0)

Upstream sequence

AAGCAAGGAAGAAAAATAAAAGTTTATATCAGGAGAAAAAGATGATTGCCCAGAGTCCGAGTTCACGAATAGCAGATATGTAAACAGCCATACTAAGTCA

Downstream sequence

AGTGGTATCTCATGTTGTAATTTATTACTTTTAAAATCAATATCCATAACACAGCTTTAGGCCCAGTTTCATGTAAGATGAATGGAAATAAAAATAATCT