Basic Information
VIS ID
TVIS44001215
Fusion event
HTLV-1-RTF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
41770700/41478502 (Hg38)
End
41770700/41478502 (Hg38)
Orient
-
Location type
Intronic
Target gene
RTF1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-196b-5p ; hsa-mir-26a-5p ; hsa-mir-5096 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-411-5p ; hsa-mir-3152-3p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-509-3p ; hsa-mir-1273f ; hsa-mir-10b-3p ; hsa-mir-6890-5p ; hsa-mir-6812-3p ; hsa-mir-4639-3p ; hsa-mir-4789-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941
Nearest miRNA
hsa-mir-1233-1/Upstream/4505601; hsa-mir-10393/Downstream/213083;
Nearest TSS
ENST00000557528/Upstream/17; ENST00000425927/Downstream/14891;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/60749, chr15-CpG: 58/Downstream/7693
Upstream sequence
aaaaaattaaaaaaaaaaaaaaaggaaaaGGATAATAGCTTTTTTTTTTTTCAGTCCCGTGCAAAGACTTATTTGCCTGTGAGCTTATGGTGAATGAGAG
Downstream sequence
GAGGGGCTGGAGGTGCAGTTCTGTGGTGCATGCTTTCTGTTTCAGGCTGAAAGTCACAACATGAAAAACCAACAGATGGATCCCTTTACTCGGCGGCAGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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