Basic Information
VIS ID
TVIS44001225
Fusion event
HTLV-1-SLC39A11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
70857535/72861396 (Hg38)
End
70857535/72861396 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC39A11
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-375 ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-4662a-5p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3620-5p ; hsa-mir-1587 ; hsa-mir-6868-3p ; hsa-mir-4291 ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-6829-5p ; hsa-mir-4656 ; hsa-mir-6882-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-378g ; hsa-mir-6787-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-922 ; hsa-mir-3134 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-3184-5p ; hsa-mir-3196 ; hsa-mir-423-5p ; hsa-mir-4459 ; hsa-mir-4519 ; hsa-mir-4534 ; hsa-mir-4722-5p ; hsa-mir-4779 ; hsa-mir-6081 ; hsa-mir-6165 ; hsa-mir-6816-5p ; hsa-mir-8082
Nearest miRNA
hsa-mir-10226/Upstream/3761740; hsa-mir-1250/Downstream/1887217;
Nearest TSS
ENST00000595228/Upstream/11592; ENST00000579323/Downstream/131536;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/220581, chr17-CpG: 113/Downstream/303387
Upstream sequence
ACCCACTGCTAAAGATAATAGAGATTTTCCATCAATAAAAGGAGGGGACTGCTGCCCTTCAAGATAGTCTACACTGCTTTGGAATATGAAGTCACTTTGT
Downstream sequence
GTTTTTTATTTTTAAATAGTGGATGCACTCCTCTCATGTCGTTTACTTAGGCTAACACTGACACAAGTTTGCACTTCCTAAAAAATGTTGCAGCCAGGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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