Basic Information
VIS ID
TVIS44001228
Fusion event
HTLV-1-G6PC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
41061540/42909523 (Hg38)
End
41061540/42909523 (Hg38)
Orient
-
Location type
Intronic
Target gene
G6PC
miRNAs that regulate target gene
hsa-mir-23a-3p ; hsa-mir-33b-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-106a-3p ; hsa-mir-3650 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-4726-3p ; hsa-mir-1298-3p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-19a-3p ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-203a-3p ; hsa-mir-4762-5p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-4536-5p ; hsa-mir-664a-3p ; hsa-mir-6074 ; hsa-mir-3163 ; hsa-mir-577 ; hsa-mir-5692a ; hsa-mir-3662 ; hsa-mir-4668-5p ; hsa-mir-1253 ; hsa-mir-4311 ; hsa-mir-574-5p ; hsa-mir-6821-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-136-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6890-3p
Nearest miRNA
hsa-mir-1180/Upstream/85580; hsa-mir-10226/Downstream/535283;
Nearest TSS
ENST00000595228/Upstream/8711; ENST00000590836/Downstream/42612;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/75618, chr17-CpG: 23/Downstream/54809
Upstream sequence
GGCTGATCTGACTCCCTTCCTTCTCCCCCAAACCCCATTCCGTTTCTCTCCCTAATCAGGACAAAATCCCAGCATTCCAGCCACATCCTGTGTGTAATCA
Downstream sequence
GTACTGTTAGCATTTCTGTGGGTTGAAAGTCAAGAATGAGCAACTTGAAATGATTAATTTCTATAAGAGTGCCCAGATCTATAGAATGAATTGTGTAGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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