Basic Information
VIS ID
TVIS44001240
Fusion event
HTLV-1-ZBTB45 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
59034897/58523530 (Hg38)
End
59034897/58523530 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZBTB45
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-5704 ; hsa-mir-1295a ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-5697 ; hsa-mir-4802-5p ; hsa-mir-4747-3p ; hsa-mir-942-3p ; hsa-mir-4802-3p ; hsa-mir-525-3p ; hsa-mir-524-3p
Nearest miRNA
hsa-let-7e/Upstream/130084; hsa-mir-6807/Downstream/26755;
Nearest TSS
ENST00000633603/Upstream/3308; ENST00000597968/Downstream/15381;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3471, chr19-CpG: 48/Downstream/14881
Upstream sequence
agcactttgagaggctgagacaggtggatcacctgaggtcaggagttcgagaccagcctggccaatatggtgaaaaccccatctctagctgggcatggtg
Downstream sequence
gcgggcacctgtaatcccaacttctctggaggctgaggcaggagaatagcttgaacctgggaggcagaggttgcagtgagccagagatcagctgtcattg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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