Basic Information
VIS ID
TVIS44001244
Fusion event
HTLV-1-HADHB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
26479538/26256670 (Hg38)
End
26479538/26256670 (Hg38)
Orient
-
Location type
Intronic
Target gene
HADHB
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-1229-3p ; hsa-mir-99a-5p ; hsa-mir-33a-5p ; hsa-mir-633 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4720-3p ; hsa-mir-4708-3p ; hsa-mir-4493 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4717-5p ; hsa-mir-3154 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4753-5p
Nearest miRNA
hsa-mir-1301/Upstream/927949; hsa-mir-10b/Downstream/1739697;
Nearest TSS
ENST00000437798/Upstream/11540; ENST00000494615/Downstream/3868;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/11131, chr2-CpG: 87/Downstream/88870
Upstream sequence
TATAATACATGACACATTTATTATCTTCTTTGATTTTAATTGTTTTTAAAGAGTATACAATGTATATCAGTCAGCcattgaattgtaggttttggagttg
Downstream sequence
gttagagcctttgaggtcatctagttcagctctaatatttgcaaataagaaaatcgtggcagagtaggCCTACAACCCAGATATTTTAGCTCTCAATTCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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