Basic Information
VIS ID
TVIS44001250
Fusion event
HTLV-1-CHGB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5903999/5923353 (Hg38)
End
5903999/5923353 (Hg38)
Orient
-
Location type
Exonic
Target gene
CHGB
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-103a-2/Upstream/2005782; hsa-mir-1-1/Downstream/1448255;
Nearest TSS
ENST00000382410/Upstream/7855; ENST00000378883/Downstream/27124;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/11582, chr20-CpG: 60/Downstream/26963
Upstream sequence
CAGGGCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGAAACTACCCCAGCTTAGAGCTTGATAAGATGGCACATGGATATGGTGAA
Downstream sequence
GAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGCCATCACAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCATGTCTGACACCAGAGAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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