Basic Information
VIS ID
TVIS44001255
Fusion event
HTLV-1-PIK3IP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31680957/31284971 (Hg38)
End
31680957/31284971 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
PIK3IP1
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1286/Upstream/124852; hsa-let-7a-3/Downstream/336496;
Nearest TSS
ENST00000624155/Upstream/12297; ENST00000440456/Downstream/5755;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/8143, chr22-CpG: 86/Downstream/5679
Upstream sequence
TTACAGCCCTCCCTCCCTAAGAGGAAGCCTGGTGCCTGCCCACCCATCCCAGCCAGGGAAAAGCTCCATCCCATTAGGCAAGCCTCATGGCCTTTGGCAG
Downstream sequence
AGCTCAAGGCTTACAGTACCTACCCTGACTGCTTGCTCCAAGGCCAGGGTGGGACTGGGAGCTGAGCTGGCCAGAGAGAGCAGGTGTAGAGGAAGCTGCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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