VISDB - VIS Detail

Basic Information

VIS ID

TVIS44001261

Fusion event

HTLV-1-PIGG integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr4

Cytoband

p16.3

Reference genome

GRCh37/hg19

Start

517437/523648 (Hg38)

End

517437/523648 (Hg38)

Orient

Location type

Exonic

Target gene

PIGG

miRNAs that regulate target gene

hsa-mir-186-5p ; hsa-let-7b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-4313 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6818-3p ; hsa-mir-106a-3p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3655 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-1304-3p ; hsa-mir-500b-3p ; hsa-mir-183-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-3664-5p ; hsa-mir-5197-5p ; hsa-mir-6836-3p ; hsa-mir-6881-3p ; hsa-mir-4633-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-3124-3p ; hsa-mir-130b-5p ; hsa-mir-877-3p ; hsa-mir-5193 ; hsa-mir-532-5p ; hsa-mir-606

Nearest miRNA

hsa-mir-571/Upstream/173396; hsa-mir-12113/Downstream/1462736;

Nearest TSS

ENST00000502981/Upstream/128; ENST00000508669/Downstream/184;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/24058, chr4-CpG: 31/Downstream/11729

Upstream sequence

AGCTTCGTGGAGGAGGAGCACCAGACCTGGTACTTCCTTGTGAACACCCTGTGTCTAGCTCTGAGCCAAGAAACCTACAGAAACTACTTTCTGGGAGATG

Downstream sequence

ACGGTGAGCCTCCGTGTGGCCTCTGTGTGGAACAAGGGCATGACGGGGCCACAGCAGCGTGGCAGGACGGGCCTGGCTGTGATGTCCTGGAGCGAGACAA

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.