Basic Information
VIS ID
TVIS44001293
Fusion event
HTLV-1-AP4M1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99700987/100103364 (Hg38)
End
99700987/100103364 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
AP4M1
Nearest miRNA
hsa-mir-10525/Upstream/9290; hsa-mir-10399/Downstream/53241;
Nearest TSS
ENST00000635602/Upstream/1278; ENST00000479916/Downstream/204;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1341, chr7-CpG: 124/Downstream/23495
Upstream sequence
aactcatggcctcaagccattctcctacgtctcggccttccaaagcgctgagagtacaggagtgagtcaccatgcctggccCCACTCCCCCTCTTTACCC
Downstream sequence
CTTCCCTCCACTGATCACTCAGACTGTCCTTCCTTTACCACTAGGACTATGGCTATGTACAGACCACATCCACGGAGATGCTGAGGAATTTCATCCAGAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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