Basic Information
VIS ID
TVIS44001304
Fusion event
HTLV-1-FANCG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
35074299/35074302 (Hg38)
End
35074299/35074302 (Hg38)
Orient
-
Location type
Intronic
Target gene
FANCG
miRNAs that regulate target gene
hsa-mir-23a-3p ; hsa-mir-193b-3p ; hsa-mir-744-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1606367; hsa-let-7a-1/Downstream/533792;
Nearest TSS
ENST00000422679/Upstream/1053; ENST00000431804/Downstream/1207;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1414, chr9-CpG: 57/Downstream/5329
Nearest cancer related gene
FANCG(TSG, No orient, 0)
Upstream sequence
ACAGGGGGAGAGACCTGGAGAGAAAGAAGGATGATGCCTAAGGGTGAAAGATTGGCAGAAAGCTGGGCAGCCATACCCCCGCTTTCAGTGTTCACCACCC
Downstream sequence
ACAATAGGTCCAAGGACTCTAGGACACCAACTGCCCCTCAGCCCCAAGCCAGCAGGCCTGAGCCTCACCACAGAGCATCTTCATGTGACCCCTTAGTTTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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