Basic Information
VIS ID
TVIS44001308
Fusion event
HTLV-1-CNTLN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
17461686/17461688 (Hg38)
End
17461686/17461688 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9G
Target gene
CNTLN
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-10a-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-222-5p ; hsa-mir-545-5p ; hsa-mir-548m ; hsa-mir-329-5p ; hsa-mir-15b-3p ; hsa-mir-3122 ; hsa-mir-3913-5p ; hsa-mir-450a-1-3p ; hsa-mir-6513-5p ; hsa-mir-6716-5p ; hsa-mir-887-5p ; hsa-mir-3672 ; hsa-mir-6818-3p ; hsa-mir-6864-3p
Nearest miRNA
hsa-mir-101-2/Upstream/11453784; hsa-let-7a-1/Downstream/1111618;
Nearest TSS
ENST00000422679/Upstream/45870; ENST00000467085/Downstream/117394;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/325980, chr9-CpG: 120/Downstream/117035
Upstream sequence
TTACCTTGGGTAATTAATAGTTTAATCTTTTCAAATTCAAATTATTTTTAGCATGAGTCAAACATCCAAACCTAGGAATAGTTCTAATAGAAAAAATTTA
Downstream sequence
TTGTAGTTTAGAAATATTAGCTAAATAACTACTCCAAATATTTTAAAAGCTATTATATTTTAttatatttatattcatttaatacctttaaaacttaaca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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