Basic Information
VIS ID
TVIS44001309
Fusion event
HTLV-1-AOPEP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
97719444/94957162 (Hg38)
End
97719444/94957162 (Hg38)
Orient
-
Location type
Intronic
Target gene
AOPEP
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-6820-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6087 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6510-5p ; hsa-mir-6089 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-518f-3p ; hsa-mir-518c-3p ; hsa-mir-518d-3p ; hsa-mir-518b ; hsa-mir-518a-3p ; hsa-mir-6849-3p ; hsa-mir-4293 ; hsa-mir-6771-3p ; hsa-mir-3180-5p ; hsa-mir-2355-5p ; hsa-mir-1236-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-4793-5p ; hsa-mir-510-5p ; hsa-mir-4786-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-1193 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-2392 ; hsa-mir-1306-5p ; hsa-mir-1343-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-4264 ; hsa-mir-4279 ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-498 ; hsa-mir-622 ; hsa-mir-660-3p ; hsa-mir-6727-3p ; hsa-mir-6742-3p ; hsa-mir-6747-3p ; hsa-mir-6783-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-let-7a-1/Upstream/147105; hsa-mir-12126/Downstream/108188;
Nearest TSS
ENST00000422679/Upstream/1216; ENST00000496567/Downstream/10622;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/230272, chr9-CpG: 164/Downstream/47205
Upstream sequence
AAGCCACTTCTCACCAAGAGACTGCAGTGTTAAATAAGTGCATTGTATTTACCATGACTTCGGAGGTTTTGATTTTCACTTCCCATGGAACTCTTACTGC
Downstream sequence
TCTCTTAACCAAACTGTTCAGTTCTTCGTTTGCTTCTCTCttttttgttgtttttttgttgttggagacagattctcctctgtcgcctaggctggagtgc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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