Basic Information
VIS ID
TVIS44001314
Fusion event
HTLV-1-CTPS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
16624259/16606136 (Hg38)
End
16624259/16606136 (Hg38)
Orient
-
Location type
Intronic
Target gene
CTPS2
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-137 ; hsa-mir-6892-5p ; hsa-mir-4742-3p ; hsa-mir-499b-5p ; hsa-mir-4494 ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-4475 ; hsa-mir-628-5p
Nearest miRNA
hsa-mir-3690-1/Upstream/3015790; hsa-let-7f-2/Downstream/20876;
Nearest TSS
ENST00000429181/Upstream/15091; ENST00000380200/Downstream/44022;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/750497, chrX-CpG: 95/Downstream/105666
Upstream sequence
TTCCCAGGCCCTAAAAGATAAATATTCTCCGCTAGGCAGAATGCGGAGGTTACACCTCAGGTACGCTTAACTCAAAGGCAAGGATTTTTACACTCCATGC
Downstream sequence
TTTAAAGACATTGGCCGTACACGTGCCATACAATTGAATATCATCAGCGCCAACTTCTGGGAAAGGAAGTCATTATTCTAGTGTTCATATTCCTTGTCAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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