Basic Information
VIS ID
TVIS44001329
Fusion event
HTLV-1-CAMK1D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
12422882/12380883 (Hg38)
End
12422882/12380883 (Hg38)
Orient
+
Location type
Intronic
Target gene
CAMK1D
miRNAs that regulate target gene
hsa-mir-6778-3p ; hsa-mir-6719-3p ; hsa-mir-150-5p ; hsa-mir-6814-5p ; hsa-mir-5697 ; hsa-mir-323a-3p ; hsa-mir-562 ; hsa-mir-145-5p
Nearest miRNA
hsa-mir-3155a/Upstream/250067; hsa-mir-107/Downstream/197870;
Nearest TSS
ENST00000439456/Upstream/31150; ENST00000615792/Downstream/379693;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/30293, chr10-CpG: 78/Downstream/620211
Nearest cancer related gene
CAMK1D(OG, No orient, 0)
Upstream sequence
aggcggagattgcagtgagctgagattgcaccactgcacttcagcctgggcaacagagcaagactctgtctcaaaaacaaacaaacaaaaaaacaaacCC
Downstream sequence
CACGCATTTCTCAGTTAATTGAAGGCTCACACATTTAGTAATGATATAATTGGCCTAGTCATTTGTCAGGTTGTTTTTGAGTTAAAATGAATGGTTTGAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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