Basic Information
VIS ID
TVIS44001334
Fusion event
HTLV-1-OPCML integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
132613524/132743629 (Hg38)
End
132613524/132743629 (Hg38)
Orient
+
Location type
Intronic
Target gene
OPCML
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-3924 ; hsa-mir-8068 ; hsa-mir-190a-3p ; hsa-mir-567 ; hsa-mir-4307 ; hsa-mir-5011-5p
Nearest miRNA
hsa-let-7a-2/Upstream/2076826; hsa-mir-4697/Downstream/1154875;
Nearest TSS
ENST00000527297/Upstream/411139; ENST00000532272/Downstream/117148;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/831991, chr11-CpG: 33/Downstream/199138
Nearest cancer related gene
OPCML(TSG, No orient, 0)
Upstream sequence
ATGAAATTTTCTTTCCTAAAATACTTTTCAAAAAGAAATGACCCTTCCCATCTCCTTGATCAGATTAGAAGAATATAACTACTTCTCTTCCTGGAATCCA
Downstream sequence
AAGGAAAAGCCAAACTTCTGTATTAGAATCCAGATTAAAACATGGATTAATCAAGCCTGCTGGTGTCACATTTTACACCACATTCCTCAGAACAGGGGGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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