Basic Information
VIS ID
TVIS44001337
Fusion event
HTLV-1-BICD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
32524317/32371383 (Hg38)
End
32524317/32371383 (Hg38)
Orient
+
Location type
Intronic
Target gene
BICD1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/6497304; hsa-let-7i/Downstream/9952317;
Nearest TSS
ENST00000382841/Upstream/3849; ENST00000497153/Downstream/28146;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/264166, chr12-CpG: 106/Downstream/27708
Upstream sequence
ATTAAATGCATATAGATCTGAAAAGACTCTTTTCCAAAATTGCTGGGATGATGACTGACTCTTTTCCCACCCATACACACTGCCAAATGGGTCAATGTTA
Downstream sequence
ATACCTTCATTGCCCTTTTTACTCCTTCTTGGCAGAAAAGTTAACACATAGCCAACATTCGAATTCTTAGTATAAACCAGACAAGGGTTCATTTCTTTAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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