Basic Information
VIS ID
TVIS44001341
Fusion event
HTLV-1-CHURC1-FNTB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
65513811/65047093 (Hg38)
End
65513811/65047093 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
CHURC1-FNTB
Nearest miRNA
hsa-mir-208a/Upstream/2324; hsa-mir-1185-1/Downstream/288024;
Nearest TSS
ENST00000550708/Upstream/19706; ENST00000557300/Downstream/6067;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/59813, chr14-CpG: 123/Downstream/54643
Upstream sequence
atgaatggctaatttctttaatttgaaaaaaaatcatacaaaccagtaagaaatggatggacaacccaactgaaaaacaggcaaaggatctgaaGAAAGA
Downstream sequence
GGTCCCAGTGAAAGAACTGTCCTTCTTACTTTTTCTACTACAACTGCCACTACTACTGGTAGCGGAGTCTTCCCAagccctcactgtatgccaggggctg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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