Basic Information
VIS ID
TVIS44001344
Fusion event
HTLV-1-CEP128 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
80957026/80490683 (Hg38)
End
80957026/80490683 (Hg38)
Orient
+
Location type
Intronic
Target gene
CEP128
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-10a-5p ; hsa-mir-6755-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-4762-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-1260a/Upstream/3224393; hsa-mir-1185-1/Downstream/13457543;
Nearest TSS
ENST00000550708/Upstream/102926; ENST00000557096/Downstream/40277;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/628695, chr14-CpG: 29/Downstream/450683
Nearby gene
CEP128(-5795) ;
Upstream sequence
ATGAATGGGCAGAGTCCTGGCATAGTCTGTTAGAAGGAGGAGGTGGGAAGTAACCTTTAGTAGTTAATCAAGCATCTTTGGAAATGGCTTTAAGACCTCC
Downstream sequence
ACTTGGGTGAGCCTCAGGACTGAATCACAGCTCGGATACCTGGGAGAACACATGATATTGGAAACCAAGTTAAAAAAAAATACTCTAGTACTTCACCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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