Basic Information
VIS ID
TVIS44001350
Fusion event
HTLV-1-GRIN2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10100739/10006882 (Hg38)
End
10100739/10006882 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRIN2A
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-3915 ; hsa-mir-4710 ; hsa-mir-657 ; hsa-mir-3679-5p ; hsa-mir-3665 ; hsa-mir-1185-5p ; hsa-mir-3928-3p ; hsa-mir-125a-3p ; hsa-mir-583 ; hsa-mir-192-3p ; hsa-mir-6806-5p ; hsa-mir-5189-3p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-5589-3p ; hsa-mir-216a-5p ; hsa-mir-216b-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6840-3p ; hsa-mir-873-5p ; hsa-mir-1228-3p ; hsa-mir-3914 ; hsa-mir-6800-3p ; hsa-mir-1276 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-3941 ; hsa-mir-2355-5p ; hsa-mir-136-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-148a-5p ; hsa-mir-3123 ; hsa-mir-3154 ; hsa-mir-3925-5p ; hsa-mir-411-5p ; hsa-mir-5010-3p ; hsa-mir-6770-5p ; hsa-mir-6832-5p ; hsa-mir-7515
Nearest miRNA
hsa-mir-1225/Upstream/4374316; hsa-mir-11401/Downstream/1299558;
Nearest TSS
ENST00000527434/Upstream/36087; ENST00000569218/Downstream/20818;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/914050, chr16-CpG: 282/Downstream/173204
Nearest cancer related gene
GRIN2A(TSG, No orient, 0)
Upstream sequence
cacaactacccttcccagactctagtaaccatccttctactctcttctgtgttcaattgttttaattttcagctcccacaaagaagtaaaaaacatgcaa
Downstream sequence
agtttgtctttctatgcctggcttatttcacttaacatagtgaccttcagtttcatccatgttgttgcaaatgacaggatctcattctttttatggctaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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