Basic Information
VIS ID
TVIS44001351
Fusion event
HTLV-1-CDH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68776593/68742690 (Hg38)
End
68776593/68742690 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
CDH1
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-193b-3p ; hsa-mir-138-5p ; hsa-mir-26b-5p ; hsa-mir-30c-5p ; hsa-mir-23a-3p ; hsa-mir-30a-5p ; hsa-mir-199a-5p ; hsa-mir-544a ; hsa-mir-204-5p ; hsa-mir-1323 ; hsa-mir-34c-5p ; hsa-mir-371a-5p ; hsa-mir-888-5p ; hsa-mir-224-5p ; hsa-mir-421 ; hsa-mir-9-3p ; hsa-mir-129-5p ; hsa-mir-203a-3p ; hsa-mir-200c-5p
Nearest miRNA
hsa-mir-1225/Upstream/509191; hsa-mir-11401/Downstream/823118;
Nearest TSS
ENST00000527434/Upstream/5338; ENST00000564745/Downstream/20604;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4249, chr16-CpG: 44/Downstream/100765
Nearest cancer related gene
CDH1(OG, No orient, 0)
Upstream sequence
gttaggctggtctacaatctggagttttgctcttgttgcccaggctgggcaaactcctggcctcaggtgatccgcccaccttggcctcccaaagtgctgg
Downstream sequence
gattacaggcgtgagccactgtgcccggccATTTCCCCTCCTTTCTGAAGGATGTGCTGAACGTTTCAGAAAACAGTATGCAGCCTCCCTAATACAATTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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