Basic Information
VIS ID
TVIS44001354
Fusion event
HTLV-1-CDK12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
37684315/39528062 (Hg38)
End
37684315/39528062 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK12
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-503-5p ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-10b-5p ; hsa-mir-4443 ; hsa-mir-6515-5p ; hsa-mir-9-5p ; hsa-mir-130b-5p ; hsa-mir-4762-5p ; hsa-mir-216b-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-4753-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-3613-3p ; hsa-mir-3617-3p ; hsa-mir-4311 ; hsa-mir-4524a-3p ; hsa-mir-545-3p ; hsa-mir-548p
Nearest miRNA
hsa-mir-1180/Upstream/230553; hsa-mir-10226/Downstream/198433;
Nearest TSS
ENST00000595228/Upstream/2195; ENST00000584336/Downstream/1820;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/66270, chr17-CpG: 51/Downstream/45396
Upstream sequence
tggaatgcaatggcgcgatcttggtgcactgcagcctctgcctcctgggttcaagcaattctcctgcctcagcctcccaagtagctgggattacaggcac
Downstream sequence
ctgccaccacacctggctaatttttttttgtatttttagtagagatggggtttcactgtgttggccaggctggtcttgaactgccgacctctggtgatcc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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