Basic Information
VIS ID
TVIS44001355
Fusion event
HTLV-1-CLTC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
57706525/59629164 (Hg38)
End
57706525/59629164 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLTC
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-99a-3p ; hsa-mir-615-3p ; hsa-mir-503-5p ; hsa-mir-484 ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-let-7e-5p ; hsa-mir-4326 ; hsa-mir-544a ; hsa-mir-543 ; hsa-mir-377-3p ; hsa-mir-381-3p ; hsa-mir-485-3p ; hsa-mir-539-3p ; hsa-mir-487a-3p ; hsa-mir-376a-5p ; hsa-mir-382-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-1236-3p ; hsa-mir-6758-3p ; hsa-mir-877-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-199a-5p ; hsa-mir-195-3p ; hsa-mir-574-3p
Nearest miRNA
hsa-mir-10226/Upstream/263010; hsa-mir-1250/Downstream/212102;
Nearest TSS
ENST00000595228/Upstream/9221; ENST00000585198/Downstream/18482;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/9245, chr17-CpG: 28/Downstream/78229
Upstream sequence
tgcttggcaaacagctgactttggatagatctcattatttaaagatgaataaTAAGGGGGAAAAACGTGTAGAGAGAACATGGTTTACAAAAACCCATCT
Downstream sequence
CTTTCTCCAGTCTCTGCAATATTCTATATTTGGTCATATTGAACTATGAAaatctaaggcaggtttctttattttaccacagatatcctcaggaaagagt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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