Basic Information
VIS ID
TVIS44001366
Fusion event
HTLV-1-TTC21B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
166750510/165894000 (Hg38)
End
166750510/165894000 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTC21B
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-513b-5p ; hsa-mir-3165 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4736 ; hsa-mir-3665 ; hsa-mir-6089 ; hsa-mir-1827 ; hsa-mir-383-3p ; hsa-mir-4457 ; hsa-mir-125b-2-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-624-3p ; hsa-mir-3974
Nearest miRNA
hsa-mir-128-1/Upstream/5486118; hsa-mir-10b/Downstream/2688943;
Nearest TSS
ENST00000437798/Upstream/3359; ENST00000597623/Downstream/13720;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/99544, chr2-CpG: 72/Downstream/59460
Upstream sequence
gaaatataaatggccaaataatttgcggccatattatTATTAAAATAATGCTATGATTTTAGACTTTATCCTGAAGCACTAACTTAAATTTTAAGCAAAG
Downstream sequence
GGTAGGTTTTGATTTTTAGAACTGATATGCTAGTCCTATGATGACCTGGAGCAGCCAGAACCtagaagctggaagatgagttgggaatctgcactagttc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate