Basic Information
VIS ID
TVIS44001376
Fusion event
HTLV-1-SLC25A18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
18057545/17577480 (Hg38)
End
18057545/17577480 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC25A18
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-let-7a-3/Downstream/186700;
Nearest TSS
ENST00000624155/Upstream/7773; ENST00000464649/Downstream/10538;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/158240, chr22-CpG: 17/Downstream/3694
Upstream sequence
ctcctgacgtcaggtgatccgcccgcctcagcctcccaaagtgctgagattataggtgtgagccaccgcacccggccCACAGTTTCTAAAGTAGTAATTT
Downstream sequence
AGTTCTAGAAACAGCAGGGAATATGATTATAAGAGCAGTCACAATGTTCTCAATTATTGGACTCCCTGGCTTCAGACAGAAACAGTTGTGTCCTGTCTAt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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