Basic Information
VIS ID
TVIS44001407
Fusion event
HTLV-1-KCNQ5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
73537871/72828148 (Hg38)
End
73537871/72828148 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
KCNQ5
miRNAs that regulate target gene
hsa-mir-190a-5p ; hsa-mir-194-3p ; hsa-mir-574-5p ; hsa-mir-6515-5p ; hsa-mir-6867-5p ; hsa-mir-7847-3p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6782-5p ; hsa-mir-5693 ; hsa-mir-675-3p ; hsa-mir-223-5p ; hsa-mir-543 ; hsa-mir-5096 ; hsa-mir-101-3p ; hsa-mir-139-5p ; hsa-mir-4999-3p ; hsa-mir-144-3p ; hsa-mir-6507-5p ; hsa-mir-4282
Nearest miRNA
hsa-mir-10398/Upstream/1424527; hsa-mir-10524/Downstream/139539;
Nearest TSS
ENST00000381078/Upstream/205976; ENST00000443915/Downstream/175848;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/204767, chr6-CpG: 22/Downstream/329713
Upstream sequence
attaattgttgggttctttattctgttccattcttctgtgtgtctgtttttatgttagtactatgctgttgtagttcctgcaggtttgtagtatatattg
Downstream sequence
aggactggtagtgtggtaccaccatctttgttctttttgctcaggattgctttggctactcagagtcctttgtggctctattcaaattgtaagtgttttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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