Basic Information
VIS ID
TVIS44001418
Fusion event
HTLV-1-LONRF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
12590375/12732866 (Hg38)
End
12590375/12732866 (Hg38)
Orient
+
Location type
Intronic
Target gene
LONRF1
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-19b-3p ; hsa-mir-1226-3p ; hsa-mir-301a-3p ; hsa-mir-27a-3p ; hsa-mir-216a-3p ; hsa-mir-27b-3p ; hsa-mir-513a-5p ; hsa-mir-506-5p ; hsa-mir-4328 ; hsa-mir-3681-3p ; hsa-mir-574-5p ; hsa-mir-19a-3p ; hsa-mir-8055 ; hsa-mir-5096 ; hsa-mir-8081 ; hsa-mir-6790-5p ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-5585-3p ; hsa-mir-2052 ; hsa-mir-3659 ; hsa-mir-3148 ; hsa-mir-1252-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-651-3p ; hsa-mir-561-3p ; hsa-mir-3117-3p ; hsa-mir-7162-3p ; hsa-mir-4649-3p ; hsa-mir-1-5p ; hsa-mir-3200-5p ; hsa-mir-1197 ; hsa-mir-7110-3p ; hsa-mir-342-3p ; hsa-mir-4639-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5562; hsa-mir-10400/Downstream/2120572;
Nearest TSS
ENST00000518652/Upstream/3479; ENST00000530150/Downstream/2760;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/67149, chr8-CpG: 223/Downstream/21187
Upstream sequence
taaactaaaaattgcttagggtagggccagggacatggtcagggtgtatgcacagaactttgtacaaagaaaatgcccaatacatatttatttcataaaA
Downstream sequence
TTAGTGAGGAAAACCTCCTGGGAAACTATCACAAGATGAAGCCATCCTTGAATCTGCAGTCAGTAAAAGCAAGGGTTTTGTCATTATCCAATGAAGAGTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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