Basic Information
VIS ID
TVIS44001453
Fusion event
HTLV-1-NDFIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
141508435/142128870 (Hg38)
End
141508435/142128870 (Hg38)
Orient
-
Location type
Intronic
Target gene
NDFIP1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-30a-5p ; hsa-mir-378a-3p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-10397/Upstream/1480944; hsa-mir-103a-1/Downstream/1550990;
Nearest TSS
ENST00000502646/Upstream/20082; ENST00000505614/Downstream/6860;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/19516, chr5-CpG: 105/Downstream/195314
Upstream sequence
AAAGTAGTGAATTTTAGTGGAGCAAACTCTTCACCTGGAAGTGTTTTTTTCCTTACCAAAGTGAAAATTGGTGGTTCTAAGAAGGCTGGAATTTATTTGC
Downstream sequence
ACTGTCATCTTTTACTATGGTGGGGGATGATCAAATTTAACATTTCCAAGTTTCCAGGAGACAGGCAGCCTATCTTATAAATATTGTCATAGAAGACCTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate