Basic Information
VIS ID
TVIS44001467
Fusion event
HTLV-1-VWA8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
42405463/41831327 (Hg38)
End
42405463/41831327 (Hg38)
Orient
+
Location type
Intronic
Target gene
VWA8
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-1229-3p ; hsa-mir-1227-3p
Nearest miRNA
hsa-mir-2276/Upstream/262932; hsa-mir-1267/Downstream/2364802;
Nearest TSS
ENST00000623511/Upstream/135208; ENST00000612345/Downstream/37076;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/372796, chr13-CpG: 71/Downstream/129417
Upstream sequence
ACAATAGAGTTAGCCTACATAGCCTCCATTCTATAAGCACTGAAGGgaggggatgctgtgtaatgcaggggataggagcatggccggtggaaccaatcag
Downstream sequence
acctgggttcaactccagctgtgcaccttactagctgaatgagtggggagagggagaacgactctatctctctaaactctcgtcttccataacgttaagg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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