Basic Information
VIS ID
TVIS44001477
Fusion event
HTLV-1-HFM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
91852971/91387414 (Hg38)
End
91852971/91387414 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
HFM1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-218-5p ; hsa-mir-2681-5p ; hsa-mir-4724-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-551b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/5029727; hsa-mir-11399/Downstream/2459418;
Nearest TSS
ENST00000473358/Upstream/34777; ENST00000497611/Downstream/17321;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/365164, chr1-CpG: 62/Downstream/16905
Upstream sequence
aaaaagcgacgtcgctatgaacgcttggccgccacaagccagttatccctgtggtaacttttctgacacctcctgcttaaaacccaaaaggtcagaagga
Downstream sequence
tcgtgaggccccgctttcacggtctgtattcgtactgaaaatcaagatcaagcgagcttttgcccttctgctccacgggaggtttctgtcctccctgagc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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