Basic Information
VIS ID
TVIS44001482
Fusion event
HTLV-1-CUL5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
107946405/108075678 (Hg38)
End
107946405/108075678 (Hg38)
Orient
+
Location type
Intronic
Target gene
CUL5
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-148b-3p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-484 ; hsa-mir-100-5p ; hsa-mir-92a-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-7-5p ; hsa-mir-205-5p ; hsa-mir-142-3p ; hsa-mir-182-5p
Nearest miRNA
hsa-mir-10392/Upstream/4225698; hsa-let-7a-2/Downstream/3272079;
Nearest TSS
ENST00000527297/Upstream/2288; ENST00000526119/Downstream/45838;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/66006, chr11-CpG: 71/Downstream/45599
Nearest cancer related gene
CUL5(TSG, No orient, 0)
Upstream sequence
agtctggagtgcagtggtgcaatcatagctgactgcagccttgaactcctgggctcaagcaatcctcccgcctcagccacctgagtttctgggactgtga
Downstream sequence
gcacataccaccacacctggctaggtttttaaagtttttctatagagacaacatctagctatgttgtttgggctggtcttgaactcctgccttagccttc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate