Basic Information
VIS ID
TVIS44001491
Fusion event
HTLV-1-MSRB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
65854908/65461128 (Hg38)
End
65854908/65461128 (Hg38)
Orient
-
Location type
Intronic
Target gene
MSRB3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-197-3p ; hsa-mir-4662a-5p ; hsa-mir-193b-5p ; hsa-mir-1193 ; hsa-mir-4716-5p ; hsa-mir-2392 ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p
Nearest miRNA
hsa-let-7i/Upstream/838523; hsa-mir-1178/Downstream/562492;
Nearest TSS
ENST00000382841/Upstream/116994; ENST00000545750/Downstream/77571;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/181658, chr12-CpG: 56/Downstream/267880
Upstream sequence
ATATCATTTATTTTTCCCAGATAGCTGCATTCTCTCATTAAACACACACACACACACCCCTAAGGCTTTTAGGTATATGAAAACTTCATCTCTTAAATGC
Downstream sequence
CAAGTGATCCAAGTGCTGGAGCTGCATCTGAGATCAGTAATTGTGCACACACACTGGTCACTGAGAGCACTGGTTCCTGTTGGACAGCACCTTGACTATT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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