Basic Information
VIS ID
TVIS44001493
Fusion event
HTLV-1-HDAC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
240055593/239133897 (Hg38)
End
240055593/239133897 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2J
Target gene
HDAC4
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-140-5p ; hsa-mir-1-3p ; hsa-mir-22-3p ; hsa-mir-30c-5p ; hsa-mir-302b-3p ; hsa-mir-9-5p ; hsa-mir-206 ; hsa-mir-3149 ; hsa-mir-587 ; hsa-mir-4686 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-381-3p ; hsa-mir-125a-5p ; hsa-mir-675-5p
Nearest miRNA
hsa-mir-10b/Upstream/47971; hsa-mir-149/Downstream/171565;
Nearest TSS
ENST00000437798/Upstream/25793; ENST00000428471/Downstream/7076;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/8857, chr2-CpG: 29/Downstream/5733
Upstream sequence
ACATTGCTGTTGCTATGTAATTTCATAAGGACGTTCCCATTTTCCTCTAAATTGTATTTTTCTAAATGTAACCACTCCCCCAGACAGTGCACATTTGTAA
Downstream sequence
AAGTTCGCTAACACAAACTGACCACAAGAGTCGGTTCTGGGCTTCCAGCGCTGGCTCAGCTTGGTCCAGACAGAAACCCAAATCGCAAGAGCCGGTGGCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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