Basic Information
VIS ID
TVIS44001497
Fusion event
HTLV-1-ACVR1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
158478083/157621571 (Hg38)
End
158478083/157621571 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACVR1C
miRNAs that regulate target gene
hsa-mir-376c-3p ; hsa-mir-376a-3p ; hsa-mir-376a-5p ; hsa-mir-376b-3p ; hsa-mir-22-3p ; hsa-mir-412-3p ; hsa-mir-147a ; hsa-mir-122-5p ; hsa-mir-6794-3p ; hsa-mir-3682-5p ; hsa-mir-6837-3p ; hsa-mir-676-5p ; hsa-mir-4639-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-4699-3p ; hsa-mir-323a-3p
Nearest miRNA
hsa-mir-128-1/Upstream/6253160; hsa-mir-10b/Downstream/1565264;
Nearest TSS
ENST00000437798/Upstream/24011; ENST00000604340/Downstream/7156;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/23972, chr2-CpG: 79/Downstream/6775
Nearest cancer related gene
ACVR1C(TSG, No orient, 0)
Upstream sequence
ATTTGTATTGTTCGGGTTTCAGGGAACCAAGTGGCCCACATGCTTTAGGGATCCAGCTTTCAAAGAACAAGAAAAACAAGGGGCTCATGGTCATGGCTAT
Downstream sequence
GTCTTCCTTCTTTTCCACAGCAAGTGTGGGAAGGGTACAACCTGCTTCCTTGGTAGAAGAGATCCCGCCACCTCTTTCCACAGACTTTCTACTTTTTCCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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